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Combined simvastatin plus ezetimibe treatment not only failed to reduce major cardiovascular events, but also was linked to an increase in cancer deaths among asymptomatic patients with aortic stenosis, according to the first report of a randomized, placebo-controlled, phase III trial.
The only positive outcome of the 1,873-patient SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) study was in the secondary end point of reduced ischemic events. Rel…